It focuses on the interactions between the various systems of a cell, including the interrelationship of DNA, RNA and protein synthesis and how these interactions are regulated. Editors (view affiliations) Rafal P. Piprek; Book . Strategies based on perturbing these pathways can shorten the rate and simplify the lineage path of ES differentiation. Transgene and knock down/out approaches, biochemical studies, and microscopic analyses are central for assessing the role of genes and the processes determining cell fate, cell growth and proliferation, cell specification, cell to cell interactions, cell to extracellular matrix interactions, the influence of nutritional and environmental factors, and the interaction with microbes. The differentiation of fibroblasts into myofibroblasts is critical for the development of fibrotic disorders, including idiopathic pulmonary fibrosis (IPF). Hematopoietic stem cells. 3. 2. I. Monroe, John Gordon, 1953- . Molecular biology / m ə ˈ l ɛ k j ʊ l ər / is the branch of biology that concerns the molecular basis of biological activity in and between cells, including molecular synthesis, modification, mechanisms and interactions. Much less is known about the role of the cell cycle at very early stages of embryonic development. Randomness of differentiation, both in vitro and in vivo, of pluripotent (multipotent) stem cells is now demonstrated to be mainly based on stochastic gene expression. Molecular biology is the study of the structure function, and makeup of the molecular building blocks of life. human and mouse stem cells), cell lines, and mouse models. B cells.

The central dogma of molecular biology describes the process in which DNA is transcribed into RNA then translated into protein. During development, it can be understood to be the result of a gene regulatory network. p. cm. Development and maintenance of multi-cellular organisms requires a coordinate communication between cells. - (Contemporary immunology) Includes index. Specific cell cycle inhibitors have stage and condition-specific effects on Pax3 and MyoG…Growth factor/serum withdrawal drives a…Growth factor/serum withdrawal drives a condensed gene expression program of early Pax3 expression…Growth factor/serum reduction drives a…In an unguided or heterogeneous…The authors declare no conflict of interest.Use of network-based cell cycle manipulation may provide an alternative strategy to generating…Attainment of the differentiated state during the final stages of somatic cell differentiation is closely tied to cell cycle progression.

Rothenberg, Ellen V. III. Disturbance of this communication may result in aberrant differentiation, malformation, tumor development, or cellular degeneration.The research in the section focuses on cell proliferation, cell differentiation, cell polarization, cell death, and the development of multi-cellular organisms. II. Series. Molecular mechanisms are investigated from the gene level to their cellular function using primary cells (e.g. This communication secures that cells behave appropriately according to their position in the body and maintain proper homeostasis. T cells.

Much less is known about the role of the cell cycle at very early stages of embryonic development. Development and maintenance of multi-cellular organisms requires a coordinate communication between cells. 138 Citations; 14 Mentions; 43k Downloads; Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 58) Log in to check access. ISBN 978-1-61737-065-6 ISBN 978-1-4757-2778-4 (eBook) DOI 10.1007/978-1-4757-2778-4 I. Molecular Cell and Developmental Biology. These results make it likely that pathways involving cell proliferation intersect at various points with pathways that regulate cell lineages in embryos and demonstrate that this knowledge can be used profitably to guide the path and effectiveness of cell differentiation of pluripotent cells.Specific cell cycle inhibitors have…Use of network-based cell cycle…In an unguided or heterogeneous differentiation setting, growth factor/serum withdrawal up-regulates the expression…Suggested summary of the proliferation/differentiation…

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